Endocrine Abstracts

Feral cat numbers in the UK are thought to number around one million and the Dogs Trust estimates it dealt with just over 110 000 stray and abandoned dogs in 2013. This scenario is common across the world and in the developing world in particular the control of feral populations is an ongoing challenge as well as a huge welfare issue. The only options currently available are expensive surgical neutering, or euthanasia of otherwise healthy animals. There is an urgent need to de...

Aims: Low circulating testosterone levels are associated with increased cardiovascular risk and there is evidence that androgens inhibit arterial lesion formation. This investigation addressed the hypothesis that androgens directly inhibit neointimal lesion formation by stimulation of vascular androgen receptor.Methods and results: Mice were generated with selective deletion of androgen receptor from vascular (endothelial or smooth muscle) cells. Castrat...